The War Is Not Yet Won

Chronic myeloid leukemia: the race is yet to be won.

Could the South Have Won the War?

Although the Confederate surrenders in April 1865 marked the end of major hostilities of the American Civil War, disputes of interpretation continue to characterise the study of the conduct and outcomes of the War. Whilst this may be simply a feature of all historiography, the extent of these interpretive disputes may well be a direct consequence of the nature of the primary sources that have s...

The Earth is not yet an artifact

n the previous article in this issue [1], Brad Allenby argues for a more active style of planetary management. He notes, " the biosphere itself, at levels from the genetic to the landscape , is increasingly a human product. " While the earth is undoubtedly being transformed by human action [2]-[4], the implications of the transformation for environmental management are in dispute. Allenby sugge...

The war on cancer: have we won the battle but lost the war?

In 1971 president Richard Nixon declared a war on cancer and announced his goal to cure cancer by 1976, the bicentennial year. Thirty nine years and more than 100 billion dollars later, the cumulative adult death rate from cancer adjusted for the size and age of the population has improved by less than 5% [1]. In comparison, the death rate for heart disease over this time period has improved by...

Anthracycline war: no victor yet.

T hirty years ago, the introduction of anthracyclines, such as doxorubicin and epirubicin, gave oncologists a more effective cytotoxic agent and commenced the drugs ' long reign as the foundation of early breast cancer therapy. But some experts now argue that with the advent of newer drugs — trastuzumab (Herceptin) and the taxanes, such as pacli-taxel (Taxol) and docetaxel (Taxotere) — there is...